defile
Definitions
To make foul, dirty, or unclean; to pollute.
To violate the sanctity of; to desecrate.
To sully or tarnish the reputation or honor of someone.
Examples
The vandals attempted to defile the historic monument with spray paint.
He felt that his reputation had been defiled by the false accusations.
The soldiers were ordered not to defile the sacred temple during their occupation.